Rediscover healing that remains ahead of its time.

Learn about Apligraf®

Bioengineered with living cells to transform wounds from chronic to acute, Apligraf is a skin substitute that's backed by unmatched clinical evidence in healing VLUs and DFUs.1-8

DFU=diabetic foot ulcer; VLU=venous leg ulcer

The challenges of healing stalled VLUs and DFUs

Discover factors that impede healing and learn why faster healing of VLUs and DFUs is important.

See challenges

Apligraf is an innovation that remains ahead of its time

Even after 20 years, Apligraf continues to be the biotech healer for stalled VLUs and DFUs.

Why Apligraf

Ready to start healing stalled wounds?

Talk to an Organogenesis Tissue Regeneration Specialist about using Apligraf to help close stalled VLUs and DFUs faster.2-8

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The timeless quality of proven results

Randomized controlled trials and real-world observational studies continue to demonstrate that Apligraf closes more VLUs and DFUs faster, which can lead to lower healthcare costs.2-10

Clinical trials
Real-world evidence
Health economic analyses

Unsurpassed access for patients*


of Medicare contractors cover Apligraf treatment for VLUs and DFUs8

View Medicare coverage details


of commercial medical policies cover Apligraf treatment for VLUs and DFUs8

View commercial coverage details
The coverage information provided shall not be construed as a statement, promise, or guarantee that reimbursement will be received. Reimbursement requirements are subject to change at any time. Check with your local payer regularly. *Insurance coverage varies by payer and is subject to change at any time. Confirm with your current applicable payer policies for up-to-date Apligraf coverage requirements and policies.

Please refer to the Apligraf Package Insert for complete prescribing information.


  1. Stone RC, et al. Sci Transl Med. 2017;9(371). doi:10.1126/scitranslmed.aaf8611
  2. Apligraf [package insert]. Canton, MA: Organogenesis Inc; 2017.
  3. Marston WA, et al. Wound Repair Regen. 2014;22(3):334-340.
  4. Treadwell T, et al. Adv Wound Care. 2018;7(3):69-76.
  5. Sabolinski ML, et al. J Comp Eff Res. 2018;7(8):797-805.
  6. Veves A, et al. Diabetes Care. 2001;24(2):290-295.
  7. Kirsner RS, et al. Wound Repair Regen. 2015;23(5):737-744.
  8. Data on file. Organogenesis Inc.
  9. Schonfeld WH, et al. Wound Repair Regen. 2000;8:251-257.
  10. Rice JB, et al. J Med Econ. 2015;18(8):586-595.