New Video: See How Apligraf® Transforms Chronic Wounds

Why choose Apligraf®.

Apligraf is a skin substitute bioengineered with living cells1-4 that helps transform wounds from chronic to acute and heal VLUs and DFUs faster.5-11

Apligraf overview

Examine how Apligraf can help heal stalled wounds by looking, functioning, and responding like healthy skin.1-4

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Apligraf product details

See how to apply Apligraf and download a factsheet with additional information.

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Proven results in clinical trials and real-world settings

Examine the clinical and real-world evidence for Apligraf, or contact an Organogenesis Tissue Regeneration Specialist today to get more information about how Apligraf can help your VLU and DFU patients.

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Please refer to the Apligraf Package Insert for complete prescribing information.


  1. Apligraf [package insert]. Canton, MA: Organogenesis Inc; 2017.
  2. Milstone LM, et al. Wounds. 2000;12(5 suppl A):12A-19A.
  3. Schmid P. Wounds. 2000;12(5 suppl A):4A-11A.
  4. Carlson M, et al. Tissue Eng Part A. 2011;17(3-4):487-493.
  5. Stone RC, et al. Sci Transl Med. 2017;9(371). doi:10.1126/scitranslmed.aaf8611
  6. Marston WA, et al. Wound Repair Regen. 2014;22(3):334-340.
  7. Treadwell T, et al. Adv Wound Care. 2018;7(3):69-76.
  8. Sabolinski ML, et al. J Comp Eff Res. 2018;7(8):797-805.
  9. Veves A, et al. Diabetes Care. 2001;24(2):290-295.
  10. Kirsner RS, et al. Wound Repair Regen. 2015;23(5):737-744.
  11. Data on file. Organogenesis Inc.