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Apligraf® commercial insurance coverage support.

When it comes to treating VLUs and DFUs, 100% of commercial medical policies cover Apligraf.*1 The commercial payer summary guidelines below show what the policies are for a number of insurance providers.

Commercial insurance coverage


of commercial medical policies cover Apligraf treatment for VLUs and DFUs*1

Commercial payer summary guidelines

Aetna Wound Care Policy #0244

Effective 05/28/1998
Last Review 01/27/2020


Anthem Medical Coverage Policy #SURG 00011

Allogeneic, Xenographic, Synthetic and Composite Products for Wound Healing and Soft Tissue Grafting

Effective 12/27/2018
Last review 11/7/2019

Source: Only Grafix Prime is covered for DFUs.

BC/BS Federal Employee Program

Bioengineered Skin and Soft Tissue Substitutes Policy #FEP7.01.113

Effective 4/1/2019


BC/BS Highmark Commercial Medical Policy—Pennsylvania #S-33-032 & #S-249-004

Effective 1/1/2019
Last Review 9/2019


Cigna Medical Policy #0068

Tissue-Engineered Skin Substitutes

Effective 2/15/19
Last review 2/15/20


Excellus Medical Coverage Policy #7.01.35

Bioengineered Tissue Products for Wound Treatment and Surgical Interventions

Effective 1/17/2002
Last review 6/20/2019


Humana Medical Policy #HCS-0370-033

Skin and Tissue Substitutes

Effective 1/28/2020
Last review 1/28/2020

Source: Grafix Core and Grafix Prime.

Medica Tissue-Engineered Skin Substitutes for Wound and Surgical Care

Effective 3/20/2019


United Health Care Commercial Medical Policy #2020T0592G

Effective 1/1/2020


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Please refer to the Apligraf Package Insert for complete prescribing information.

The coverage information provided shall not be construed as a statement, promise, or guarantee that reimbursement will be received. Reimbursement requirements are subject to change at any time. Check with your local payer regularly. *Insurance coverage varies by payer and is subject to change at any time. Confirm with your current applicable payer policies for up-to-date Apligraf coverage requirements and policies. EpiFix is a registered trademark of MiMedx Group Inc. Grafix is a registered trademark of Osiris Therapeutics, Inc. TheraSkin is a registered trademark of Solsys Medical, LLC.


  1. Data on file. Organogenesis Inc.