Apligraf® product details.

See how to apply Apligraf and view additional resources.

How to apply Apligraf1,2

Preparing the wound bed

Apply Apligraf to a clean, noninfected, and debrided wound after irrigating the wound with a noncytotoxic solution. Ensure hemostasis following debridement.

Step 1: Preparing Apligraf

1A

Before opening, check the package's expiration date and pH to ensure both are within range

1B

Apligraf is packaged with the epidermal (matte) side facing up and the dermal (glossy) side facing down

  • The dermal side rests on a polycarbonate membrane; be sure to not inadvertently remove it with Apligraf
1C

Open the pack and remove Apligraf using aseptic techniques

  • Gently remove by lifting from the edge
  • Apligraf must be used within 15 minutes of opening
1D

Prior to application, Apligraf may be placed on a saline-soaked gauze and/or fenestrated to allow for drainage

Expiration date and pH ranges for Apligraf 1A
Apligraf with the epidermal (matte) side facing up 1B
Apligraf lifted from its container with forceps 1C
Apligraf placed on saline-soaked gauze for drainage 1D

Step 2: Applying Apligraf

2A

Place Apligraf over the wound with the dermal (glossy) side directly in contact with the wound surface

2B

Using a saline-moistened cotton tip applicator, smooth Apligraf onto the wound bed so there are no pockets or wrinkled edges

Apligraf applied directly in contact with the wound surface 2A-2B

Step 3: Applying dressing

3A

Cover Apligraf using a non-adhesive primary dressing

3B

Anchor Apligraf using clinician’s choice of fixation

3C

Apply a secondary, non-occlusive dressing to create a bolster

Apligraf covered with a non-adhesive primary dressing 3A-3B

Compress/offload and follow-up

  • Apligraf should always be used with appropriate compression or offloading as well as good wound-care practices
  • Reassess the wound weekly, and reapply Apligraf weekly as long as the wound continues to respond*
  • Debride the wound while not disrupting healing tissue
  • Clean the wound with a noncytotoxic solution
Doctor wrapping a leg in compression after applying Apligraf
Foot offloaded after receiving an Apligraf treatment
Wound that reduced in size with the help of Apligraf
*The safety and effectiveness of Apligraf have not been established for patients receiving greater than 5 device applications. In the pivotal trials for VLUs and DFUs, patients received up to 5 applications (over 3 weeks for VLUs and over 4 weeks for DFUs). The average number of applications per VLU patient was 3.3 and the average number for DFU patients was 3.9.1-3

Downloadable resources

Apligraf factsheet

Proven results in clinical trials and real-world settings

Examine the clinical and real-world evidence for Apligraf, or contact an Organogenesis Tissue Regeneration Specialist today to get more information about how Apligraf can help your VLU and DFU patients.

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REFERENCES:

  1. Apligraf [package insert]. Canton, MA: Organogenesis Inc; 2017.
  2. Data on file. Organogenesis Inc.
  3. Veves A, et al. Diabetes Care. 2001;24(2):290-295.