Apligraf^® product details.

See how to apply Apligraf to VLUs and DFUs. Also, view additional resources.

How to apply Apligraf

Diabetic foot ulcer application

Venous leg ulcer application

Application steps^1,2

Preparing the wound bed

Apply Apligraf to a clean, noninfected, and debrided wound after irrigating the wound with a noncytotoxic solution. Ensure hemostasis following debridement.

Step 1: Preparing Apligraf

Before opening, check the package's expiration date and pH to ensure both are within range

Apligraf is packaged with the epidermal (matte) side facing up and the dermal (glossy) side facing down

The dermal side rests on a polycarbonate membrane; be sure to not inadvertently remove it with Apligraf

Open the pack and remove Apligraf using aseptic techniques

Gently remove by lifting from the edge
Apligraf must be used within 15 minutes of opening

Prior to application, Apligraf may be placed on a saline-soaked gauze and/or fenestrated to allow for drainage

Expiration date and pH ranges for Apligraf

Apligraf with the epidermal (matte) side facing up

Apligraf lifted from its container with forceps

Apligraf placed on saline-soaked gauze for drainage

Step 2: Applying Apligraf

Place Apligraf over the wound with the dermal (glossy) side directly in contact with the wound surface

Using a saline-moistened cotton tip applicator, smooth Apligraf onto the wound bed so there are no pockets or wrinkled edges

Apligraf applied directly in contact with the wound surface

2A-2B

Step 3: Applying dressing

Cover Apligraf using a non-adhesive primary dressing

Anchor Apligraf using clinician’s choice of fixation

Apply a secondary, non-occlusive dressing to create a bolster

Apligraf covered with a non-adhesive primary dressing

3A-3B

Compress/offload and follow-up

Apligraf should always be used with appropriate compression or offloading as well as good wound-care practices
Reassess the wound weekly, and reapply Apligraf weekly as long as the wound continues to respond^*
Debride the wound while not disrupting healing tissue
Clean the wound with a noncytotoxic solution

Doctor wrapping a leg in compression after applying Apligraf

Foot offloaded after receiving an Apligraf treatment

Wound that reduced in size with the help of Apligraf

^*The safety and effectiveness of Apligraf have not been established for patients receiving greater than 5 device applications. In the pivotal trials for VLUs and DFUs, patients received up to 5 applications (over 3 weeks for VLUs and over 4 weeks for DFUs). The average number of applications per VLU patient was 3.3 and the average number for DFU patients was 3.9.^1-3

Downloadable resources

Apligraf factsheet

Product Number	Apligraf Product Description	Total Size (cm²)	Billable Units	HCPCS Code	UDI Number
APLIGRAF-COM	Apligraf (living, bi-layered skin substitute)	44	44	Q4101	00618474000008

Proven results in clinical trials and real-world settings

Examine the clinical and real-world evidence for Apligraf, or contact an Organogenesis Tissue Regeneration Specialist today to get more information about how Apligraf can help your VLU and DFU patients.

Please refer to the Apligraf Package Insert for complete prescribing information.

REFERENCES:

Apligraf [package insert]. Canton, MA: Organogenesis Inc; 2017.
Data on file. Organogenesis Inc.
Veves A, et al. Diabetes Care. 2001;24(2):290-295.

Apligraf® product details.